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pentobarbital will decrease the extent or outcome of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; prevent use in sufferers who're chronically utilizing a solid CYP3A4 inducerBarbiturates may be practice forming. Tolerance, psychologic